Mesenchymal Stem Cell Therapy For Osteoarthritis (Rejoint) - Advance Knee Resurgence Therapy
Osteoarthritis is often believed to be an old man’s disease but is this really true? While the disease can cause significant mobility issues, these dreaded lifelong impacts means permanent change in a person’s lifestyle. The Mesenchymal Stem Cell Therapy For Osteoarthritis also known as Rejoint aims to challenge the plight of knee osteoarthritis by reversing the progress so the patients may feel young and free to be themselves again.
What is Osteoarthritis (OA)?
Osteoarthritis (OA) affects the cartilage in the area where the bones meet to form a joint. Repeated motion on the joints causes wear and wear and over time, the impacts became more pronounced when a person gets older. As the cartilage wears thin, the contact between joints become less fluid and movement results painful when they rub on each other. The problem can result at any joints but they are usually more pronounced among the knees, hips, and spine, as well as the hands and fingers.
Some risk factors such as aging, obesity, genetics, and activities can cause repetitive joint stress and worsen the condition. Common symptoms such as pain, stiffness, and reduced range of motion are the telltale signs for deterioration of cartilage.
Staging of OA
The staging of OA can be divided into 5 phases to help healthcare providers understand the severity of the diseases.
- Stage 0 (Normal): In this stage, there are no signs of osteoarthritis. The joint appears normal, with no significant cartilage loss, bone spurs, or other changes associated with OA. In other words, the bones are healthy.
- Stage 1 (Doubtful): This stage shows minor joint space narrowing, which could be caused by issues beyond osteoarthritis. Some small changes can be noticed but there are no definite signs that it could be arthritis. Some people with Stage 1 fmight not experience any symptoms.
- Stage 2 (Mild): Mild joint space narrowing and presence of small bone spurs (osteophytes) are detected. Cartilage loss becomes more evident, and individuals may experience mild pain and stiffness in the affected joint, especially after periods of inactivity or intense activity such as exercise.
- Stage 3 (Moderate): The joint space narrowing becomes more pronounced, and there is more significant cartilage loss and bone changes. The individual may feel noticeable pain, stiffness, and reduced joint function that affect daily activities. Bone spurs growth increases in size and number. At this stage, the quality of life starts to decline.
- Stage 4 (Severe): The most advanced stage of OA, Stage 4 is characterized by severe joint space narrowing, extensive cartilage loss, significant bone spurs, and often visible deformities. Joint function and mobility are limited, and individuals may experience chronic pain and restricted range of motion. This stage can significantly impact a person’s ability to live a normal life and may call for more aggressive treatment, including joint replacement surgery.
Long Term Complications of OA
If left untreated, OA can result in permanent complications that reduces the person’s quality of life. These are the complications of long term OA:
Long Term Complications of OA
Cartillage exists to ease the movement of bones when they rub against other. When the cartilage wears down and the bones rub against each other, pain and discomfort becomes apparent. Everytime the person moves the affected joints, the pain is hard to bear.
Reduced mobility
When the pain becomes too much, the person is unlikely to move about to reduce the movement of joints. As a result, basic movement such as walking and climbing stairs become an issue. The affected person will likely face greater difficulty to live a normal routine and imminent physical inactivity becomes inevitable.
Bone deformities
Osteoarthritis can leads to formation of bone spurs. The bone spurs can cause damage to bones, muscles, or tendons. The deformities can lead to joint instability and abnormal joint mechanics, exacerbating pain and functional limitations. If the deformities cause pain, surgical options are the only option to find relief.
How Mesenchymal stem cells (MSCs) work in OA?
The promising potency of MSCs to promote tissue repair and modulate inflammation is useful for QA. The cells have the ability to differentiate into other types including chondrocytes (cartilage cells).
Tissue repair and regeneration
MSC can secrete growth factors, cytokines, and other signaling molecules that promote tissue repair and regeneration. Local cells are stimulated to create more similar cells to aid the healing of damaged tissue.
Reduced inflammation
Inflammation occurs when the breakaway cartilage irritates the lining of joints. The immune system will be stressed out to remove the substance from the body. The inflammation also causes pain and joint damage. MSC can secrete factors that suppress the activity of immune cells and decrease the inflammatory responses.
Pain reduction
The anti-inflammatory and tissue-repairing effects of MSC stem cell therapy can lead to a reduction in pain linked to osteoarthritis. By addressing the underlying factors contributing to pain, MSC-based treatments can provide long-lasting relief for better quality of life.
Specialty of MSCs in Treating OA
MSC-based stem cell therapy such as Rejoint offer more than a cutting-edge technology, it offers a series of unique advantages that transforms how OA is treated.
- No side effects: The treatment leaves no short or term effects.
- Minimally invasive: Nos surgery is needed and there are no open incision to administer the treatment.
- Resolve OA pathology: The treatment surpasses conventional treatments whereby the normal methods unable to reverse the loss of articular cartilage
- Zero risk of immune rejection: The MSCs have low immunogenecity which can evade the detection of immune system.
- Safe and natural: The therapy involves no genetic modification of cells which retains the genetic integrity of the knee osteoarthritis and others
- Effective and high efficiency: The therapy is clinically proven to work and the results can provide immense relief
How MSCs different From Conventional Treatment?
Revine Clinic MSCs Production Flow
The production flow of MSC is well-defined and every phase refines the cells before eventual use.
- Tissue Collection: The tissue containing MSCs is collected from the donor. The collection sources is typically umbilical cord tissue but others such as bone marrow and adipose tissue (fat) may also be considered.
- Tissue Processing and Isolation: The collected tissue is processed to extract MSCs. This phase is important to release the cells from the tissue.
- Cell Isolation and Expansion: MSCs are isolated from the cell mixture through specific methods. Isolated MSCs are then cultured in a controlled environment with specific growth factors, nutrients, and culture media to enhance the expansion.
- Quality Control and Characterization: During and after the expansion stage, MSCs undergo strict quality control. This stage iassesses different factors such as morphology, growth rate, surface marker expression, and differentiation potential. These tests maintains the authenticity of MSCs for Rejoint.
- Cryopreservation: Once a sufficient number of MSCs is obtained, they are cryopreserved (frozen) for future use. The cryopreservation helps maintain cell viability and functionality during storage.
- Injection: The formulated MSCs are injected into the affected joints during the MSC Therapy For Osteoarthritis.
Case Study About Effectiveness & Efficacy of MSCs in Cartilage Repair & Regeneration
Consult with Revine Clinic to Get more information about Mesenchymal Stem Cell Therapy For Osteoarthritis (Rejoint)
Osteoarthritis is a disease that stop people from living their best lives. Health issues such as knee osteoarthritis can keep people grounded from reaching for their dreams. For older individuals, Mesenchymal Stem Cell Therapies For Osteoarthritis provide a second chance to be free to move again without pain again.
While other conventional treatments may deliver lacklustre results, Rejoint delivers high performance results. Get in touch with Revine Clinic to book a consultation and take charge of your mobility today.
FAQs
What is the role of mesenchymal stem cells in osteoarthritis treatment?
Mesenchymal stem cells play a role in osteoarthritis treatment by promoting tissue repair, reducing inflammation, and potentially differentiating into cartilage-like cells to help regenerate damaged joint tissues.
Does stem cell therapy work for osteoarthritis?
Yes, the result is permanent. The damaged cells are replaced to regenerate the cartilage and help joints move normally without pain.
What is the success rate of stem cell therapy for osteoarthritis?
The success rate of stem cell therapies for osteoarthritis varies widely depending on factors such as the source of stem cells, the severity of the condition, the treatment protocol, and individual patient responses.